Meta-Analysis the Effect of Oral Combination Contraceptive on Hypertension and Stroke

Background: Combined oral contraceptives are a form of contraception that considered safe and effective for some women, but this does not rule out the possibility combined contribute to adverse health effects. Several epidemiological studies have shown effects on women's health. The use contraceptive pills containing hormones estrogen progesterone can cause an increase in blood pressure also stroke if used continuously. purpose study was estimate magnitude risk using incidence hypertension with meta-analysis study. Subjects Method : This research is systematic review PRISMA flowchart diagram guidelines. article search process carried between 2007-2022 3 databases, including Google Scholar, PubMed, Science Direct. keywords database were “oral contraceptive” OR “contraceptive pills” “combined AND “hypertension” “blood pressure” “stroke” “women reproductive age”. inclusion criteria full text articles case control observational methods, English, multivariate analysis adjusted Odds Ratio results. Articles met requirements analyzed RevMan 5.3 application. Result: A total 14 case-control designs originating from China, Ethiopia, United States, Italy, Netherlands Meta-analysis 7 showed effect 1.44 times compared those who did (aOR = 1.44; 95% CI 1.12 1.84; p 0.004). Meanwhile, by 2.08 2.08; 1.48 2.92; < 0.001). Conclusion: stroke. Keywords: contraceptives, hypertension, stroke, Correspondence: Ulul Azmi Zuhaira. Masters Program Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Jawa Tengah. Email: [email protected]. Mobile: +6282245012258. Journal Maternal Child Health (2022), 07(05): 520-531 https://doi.org/10.26911/thejmch.2022.07.05.03